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Compound Detail

CHEMBL85923

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O=c1[nH]c(=O)n(C2CO[C@@H](CO)O2)cc1/C=C/Br

Basic Information

ChEMBL ID CHEMBL85923
Phase Preclinical
Structure Type MOL
InChI Key YNWUIBSEOAWSHW-AHHIOEJQSA-N
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names

Molecular Properties

319.1
MW (Da)
-0.23
ALogP
6
HBA
2
HBD
93.5
PSA (Ų)
0.80
QED
0
Ro5 Violations
3
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C10H11BrN2O5
MW 319.11
Aromatic Rings 1
Heavy Atoms 18
NP-Likeness 0.70

Activity Summary

EC50 1 meas. best 4.58

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Human alphaherpesvirus 3
CHEMBL613132
EC50 4.58 4.58 26000.0 1

Activity Data Samples

Top measurements by pChEMBL value

Target Type Rel. Value Units pChEMBL Assay PubMed
Human alphaherpesvirus 3 EC50 = 26000.0 nM 4.58 Effective concentration to show 50% of activity was measured on varicella zoster... 10891113

Literature References

PubMed DOI Target Context # Activities
10891113 10.1021/jm990543n ADMET 2
10891113 10.1021/jm990543n Human alphaherpesvirus 3 1
10891113 10.1021/jm990543n Human gammaherpesvirus 4 1
10891113 10.1021/jm990543n CCRF-CEM 1

Data from ChEMBL 36 via Core Engine