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Assay Detail

CHEMBL816381

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Effective concentration to show 50% of activity was measured on varicella zoster virus(VZV) cell culture
16
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Human alphaherpesvirus 3
Confidence 1 — Organism
Curated By Expert

Target

Human alphaherpesvirus 3 (CHEMBL613132)
Type ORGANISM
Organism Human alphaherpesvirus 3

Publication

Structure-activity relationships of (E)-5-(2-bromovinyl)uracil and related pyrimidine nucleosides as antiviral agents for herpes viruses.
Choi Y, Li L, Grill S, Gullen E, Lee CS, Gumina G, Tsujii E, Cheng YC, Chu CK.
J Med Chem (2000) 43 : 2538 -2546
PubMed 10891113 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 16 6.62 9.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL2092771 2 9.00
CHEMBL86202 1 7.46
CHEMBL31634 BRIVUDINE 2.0 1 7.30
CHEMBL314382 1 7.16
CHEMBL81962 1 6.82
CHEMBL184 ACYCLOVIR 4.0 1 5.70
CHEMBL86238 1 4.90
CHEMBL85923 1 4.58
CHEMBL312839 1 -
CHEMBL87439 1 -
CHEMBL83129 1 -
CHEMBL87698 1 -
CHEMBL441063 1 -
CHEMBL2364540 1 -
CHEMBL2364538 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL2092771 EC50 = 1.0 nM 9.00
CHEMBL86202 EC50 = 35.0 nM 7.46
CHEMBL31634 BRIVUDINE EC50 = 50.0 nM 7.30
CHEMBL314382 EC50 = 70.0 nM 7.16
CHEMBL81962 EC50 = 150.0 nM 6.82
CHEMBL184 ACYCLOVIR EC50 = 2000.0 nM 5.70
CHEMBL86238 EC50 = 12500.0 nM 4.90
CHEMBL85923 EC50 = 26000.0 nM 4.58
CHEMBL2092771 EC50 > 50000.0 nM -
CHEMBL312839 EC50 > 30000.0 nM -
CHEMBL87439 EC50 > 30000.0 nM -
CHEMBL83129 EC50 > 30000.0 nM -
CHEMBL87698 EC50 > 30000.0 nM -
CHEMBL441063 EC50 > 30000.0 nM -
CHEMBL2364540 EC50 > 50000.0 nM -
CHEMBL2364538 EC50 > 50000.0 nM -