Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL677676

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Displacement of [3H]U-86170 from Dopamine receptor D2
31
Total Activities
31
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Expert

Target

D(2) dopamine receptor (CHEMBL339)
Type SINGLE PROTEIN
Organism Rattus norvegicus

Publication

C-9 and N-substituted analogs of cis-(3aR)-(-)-2,3,3a,4,5,9b-hexahydro-3- propyl-1H-benz[e]indole-9-carboxamide: 5-HT1A receptor agonists with various degrees of metabolic stability.
Haadsma-Svensson SR, Svensson K, Duncan N, Smith MW, Lin CH.
J Med Chem (1995) 38 : 725 -734
PubMed 7861420 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 31 7.32 8.49

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL164195 1 8.49
CHEMBL163469 1 7.75
CHEMBL349604 1 7.66
CHEMBL161940 1 7.47
CHEMBL161891 1 7.39
CHEMBL354455 1 7.33
CHEMBL423612 1 7.26
CHEMBL421848 1 7.21
CHEMBL421839 1 7.14
CHEMBL162767 1 7.12
CHEMBL56 8-OH-DPAT 1 7.07
CHEMBL351234 1 7.04
CHEMBL163134 1 6.92
CHEMBL350145 1 6.60
CHEMBL441486 1 -
CHEMBL163135 1 -
CHEMBL355601 1 -
CHEMBL163619 1 -
CHEMBL159625 1 -
CHEMBL161890 1 -
CHEMBL349003 1 -
CHEMBL352887 1 -
CHEMBL162167 1 -
CHEMBL160040 1 -
CHEMBL351857 1 -
CHEMBL349502 1 -
CHEMBL159886 1 -
CHEMBL162035 1 -
CHEMBL163258 1 -
CHEMBL162227 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL164195 Ki = 3.2 nM 8.49
CHEMBL163469 Ki = 18.0 nM 7.75
CHEMBL349604 Ki = 22.0 nM 7.66
CHEMBL161940 Ki = 34.0 nM 7.47
CHEMBL161891 Ki = 41.0 nM 7.39
CHEMBL354455 Ki = 47.0 nM 7.33
CHEMBL423612 Ki = 55.0 nM 7.26
CHEMBL421848 Ki = 62.0 nM 7.21
CHEMBL421839 Ki = 73.0 nM 7.14
CHEMBL162767 Ki = 75.0 nM 7.12
CHEMBL56 8-OH-DPAT Ki = 86.0 nM 7.07
CHEMBL351234 Ki = 91.0 nM 7.04
CHEMBL163134 Ki = 119.0 nM 6.92
CHEMBL350145 Ki = 252.0 nM 6.60
CHEMBL161904 Ki > 1000.0 nM -
CHEMBL441486 Ki > 1000.0 nM -
CHEMBL163135 Ki > 1000.0 nM -
CHEMBL355601 Ki > 1000.0 nM -
CHEMBL163619 Ki > 1000.0 nM -
CHEMBL159625 Ki > 1000.0 nM -
CHEMBL161890 Ki > 1000.0 nM -
CHEMBL349003 Ki > 1629.0 nM -
CHEMBL352887 Ki > 1000.0 nM -
CHEMBL162167 Ki > 1000.0 nM -
CHEMBL160040 Ki > 1000.0 nM -
CHEMBL351857 Ki > 1000.0 nM -
CHEMBL349502 Ki > 1000.0 nM -
CHEMBL159886 Ki > 1000.0 nM -
CHEMBL162035 Ki > 1000.0 nM -
CHEMBL163258 Ki > 1000.0 nM -
CHEMBL162227 Ki > 1000.0 nM -