Assay Detail
Functional
CHEMBL677884
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of autophosphorylation of epidermal growth factor receptor (EGF-R) in a cellular assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
7-Pyrrolidinyl- and 7-piperidinyl-5-aryl-pyrrolo[2,3-d]pyrimidines--potent inhibitors of the tyrosine kinase c-Src.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 5.11 | 5.11 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL168661 | — | — | 1 | 5.11 |
| CHEMBL169780 | — | — | 1 | - |
| CHEMBL169200 | — | — | 1 | - |
| CHEMBL262276 | — | — | 1 | - |
| CHEMBL169920 | — | — | 1 | - |
| CHEMBL408683 | — | — | 1 | - |
| CHEMBL355019 | — | — | 1 | - |
| CHEMBL172514 | — | — | 1 | - |
| CHEMBL263528 | — | — | 1 | - |
| CHEMBL274732 | — | — | 1 | - |
| CHEMBL171545 | — | — | 1 | - |
| CHEMBL168921 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL168661 | — | IC50 | = | 7800.0 | nM | 5.11 |
| CHEMBL169780 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL169200 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL262276 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL169920 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL408683 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL355019 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL172514 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL263528 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL274732 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL171545 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL168921 | — | IC50 | > | 10000.0 | nM | - |