Assay Detail
Functional
CHEMBL678033
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In vitro muscarinic activity was measured on isolated guinea pig ileum
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cavia porcellus |
| Tissue | Ileum |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Dimethylsulfonium and thiolanium analogues of the muscarinic agent oxotremorine.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 5 | 6.65 | 7.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL23957 | OXOTREMORINE METHIODIDE | — | 1 | 7.64 |
| CHEMBL540395 | — | — | 1 | 7.54 |
| CHEMBL553214 | — | — | 1 | 6.60 |
| CHEMBL541927 | — | — | 1 | 6.39 |
| CHEMBL554629 | — | — | 1 | 5.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL23957 | OXOTREMORINE METHIODIDE | EC50 | = | 23.0 | nM | 7.64 |
| CHEMBL540395 | — | EC50 | = | 29.0 | nM | 7.54 |
| CHEMBL553214 | — | EC50 | = | 250.0 | nM | 6.60 |
| CHEMBL541927 | — | EC50 | = | 410.0 | nM | 6.39 |
| CHEMBL554629 | — | EC50 | = | 7900.0 | nM | 5.10 |