Assay Detail
Functional
CHEMBL678034
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In vitro muscarinic activity was measured on isolated guinea pig urinary bladder
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cavia porcellus |
| Tissue | Urinary bladder |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Dimethylsulfonium and thiolanium analogues of the muscarinic agent oxotremorine.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 6.21 | 6.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL540395 | — | — | 1 | 6.70 |
| CHEMBL23957 | OXOTREMORINE METHIODIDE | — | 1 | 6.43 |
| CHEMBL553214 | — | — | 1 | 5.92 |
| CHEMBL541927 | — | — | 1 | 5.77 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL540395 | — | EC50 | = | 200.0 | nM | 6.70 |
| CHEMBL23957 | OXOTREMORINE METHIODIDE | EC50 | = | 370.0 | nM | 6.43 |
| CHEMBL553214 | — | EC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL541927 | — | EC50 | = | 1700.0 | nM | 5.77 |