Assay Detail
Functional
CHEMBL678037
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of electrically evoked contraction in guinea pig ileum determined in vitro
29
Total Activities
29
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cavia porcellus |
| Tissue | Ileum |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Design, synthesis, and pharmacological evaluation of ultrashort- to long-acting opioid analgetics.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 29 | 7.28 | 9.06 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL68570 | — | — | 1 | 9.06 |
| CHEMBL305770 | — | — | 1 | 8.98 |
| CHEMBL444584 | — | — | 1 | 8.97 |
| CHEMBL290429 | CARFENTANIL | 2.0 | 1 | 8.89 |
| CHEMBL68093 | — | — | 1 | 8.75 |
| CHEMBL596 | FENTANYL | 4.0 | 1 | 8.75 |
| CHEMBL634 | ALFENTANIL | 4.0 | 1 | 8.70 |
| CHEMBL1005 | REMIFENTANIL | 4.0 | 1 | 8.45 |
| CHEMBL71511 | — | — | 1 | 8.36 |
| CHEMBL658 | SUFENTANIL | 4.0 | 1 | 8.13 |
| CHEMBL308647 | — | — | 1 | 7.99 |
| CHEMBL68843 | — | — | 1 | 7.97 |
| CHEMBL69117 | — | — | 1 | 7.82 |
| CHEMBL420187 | — | — | 1 | 7.82 |
| CHEMBL305280 | — | — | 1 | 7.75 |
| CHEMBL71864 | — | — | 1 | 7.48 |
| CHEMBL70723 | — | — | 1 | 7.38 |
| CHEMBL70344 | — | — | 1 | 7.31 |
| CHEMBL71040 | — | — | 1 | 7.17 |
| CHEMBL419818 | — | — | 1 | 7.01 |
| CHEMBL68090 | — | — | 1 | 6.35 |
| CHEMBL68885 | — | — | 1 | 5.78 |
| CHEMBL1001 | — | — | 1 | 5.71 |
| CHEMBL70482 | — | — | 1 | 5.44 |
| CHEMBL70304 | — | — | 1 | 5.27 |
| CHEMBL71234 | — | — | 1 | 5.26 |
| CHEMBL72486 | — | — | 1 | 4.99 |
| CHEMBL71500 | — | — | 1 | 4.90 |
| CHEMBL70778 | — | — | 1 | 4.73 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL68570 | — | EC50 | = | 0.865 | nM | 9.06 |
| CHEMBL305770 | — | EC50 | = | 1.04 | nM | 8.98 |
| CHEMBL444584 | — | EC50 | = | 1.08 | nM | 8.97 |
| CHEMBL290429 | CARFENTANIL | EC50 | = | 1.3 | nM | 8.89 |
| CHEMBL68093 | — | EC50 | = | 1.79 | nM | 8.75 |
| CHEMBL596 | FENTANYL | EC50 | = | 1.76 | nM | 8.75 |
| CHEMBL634 | ALFENTANIL | EC50 | = | 2.01 | nM | 8.70 |
| CHEMBL1005 | REMIFENTANIL | EC50 | = | 3.55 | nM | 8.45 |
| CHEMBL71511 | — | EC50 | = | 4.35 | nM | 8.36 |
| CHEMBL658 | SUFENTANIL | EC50 | = | 7.43 | nM | 8.13 |
| CHEMBL308647 | — | EC50 | = | 10.2 | nM | 7.99 |
| CHEMBL68843 | — | EC50 | = | 10.8 | nM | 7.97 |
| CHEMBL69117 | — | EC50 | = | 15.0 | nM | 7.82 |
| CHEMBL420187 | — | EC50 | = | 15.0 | nM | 7.82 |
| CHEMBL305280 | — | EC50 | = | 17.8 | nM | 7.75 |
| CHEMBL71864 | — | EC50 | = | 33.0 | nM | 7.48 |
| CHEMBL70723 | — | EC50 | = | 42.0 | nM | 7.38 |
| CHEMBL70344 | — | EC50 | = | 48.8 | nM | 7.31 |
| CHEMBL71040 | — | EC50 | = | 67.0 | nM | 7.17 |
| CHEMBL419818 | — | EC50 | = | 97.0 | nM | 7.01 |
| CHEMBL68090 | — | EC50 | = | 450.0 | nM | 6.35 |
| CHEMBL68885 | — | EC50 | = | 1660.0 | nM | 5.78 |
| CHEMBL1001 | — | EC50 | = | 1950.0 | nM | 5.71 |
| CHEMBL70482 | — | EC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL70304 | — | EC50 | = | 5390.0 | nM | 5.27 |
| CHEMBL71234 | — | EC50 | = | 5440.0 | nM | 5.26 |
| CHEMBL72486 | — | EC50 | = | 10300.0 | nM | 4.99 |
| CHEMBL71500 | — | EC50 | = | 12700.0 | nM | 4.90 |
| CHEMBL70778 | — | EC50 | = | 18700.0 | nM | 4.73 |