Assay Detail
Binding
CHEMBL678341
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Affinity against the dopamine receptor D2 using [3H]spiperinone.
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
N-aryl-N'-benzylpiperazines as potential antipsychotic agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 28 | 7.53 | 9.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL428175 | RWJ-25730 | — | 1 | 9.10 |
| CHEMBL54 | HALOPERIDOL | 4.0 | 1 | 8.85 |
| CHEMBL10085 | MAZAPERTINE | 2.0 | 1 | 8.66 |
| CHEMBL135135 | — | — | 1 | 8.30 |
| CHEMBL134304 | — | — | 1 | 7.80 |
| CHEMBL1161079 | — | — | 1 | 7.77 |
| CHEMBL423712 | — | — | 1 | 7.70 |
| CHEMBL1161087 | — | — | 1 | 7.66 |
| CHEMBL443546 | — | — | 1 | 7.64 |
| CHEMBL275045 | — | — | 1 | 7.64 |
| CHEMBL1161096 | — | — | 1 | 7.55 |
| CHEMBL334767 | — | — | 1 | 7.51 |
| CHEMBL1161088 | — | — | 1 | 7.51 |
| CHEMBL3392290 | — | — | 1 | 7.50 |
| CHEMBL10105 | — | — | 1 | 7.34 |
| CHEMBL135676 | — | — | 1 | 7.29 |
| CHEMBL1161120 | — | — | 1 | 7.28 |
| CHEMBL341402 | — | — | 1 | 7.25 |
| CHEMBL1161083 | — | — | 1 | 7.24 |
| CHEMBL1161076 | — | — | 1 | 7.20 |
| CHEMBL1161078 | — | — | 1 | 7.19 |
| CHEMBL340268 | — | — | 1 | 7.06 |
| CHEMBL135107 | — | — | 1 | 7.05 |
| CHEMBL135938 | — | — | 1 | 7.05 |
| CHEMBL416703 | — | — | 1 | 6.92 |
| CHEMBL135129 | — | — | 1 | 6.70 |
| CHEMBL439607 | — | — | 1 | 6.52 |
| CHEMBL134951 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL428175 | RWJ-25730 | Ki | = | 0.8 | nM | 9.10 |
| CHEMBL54 | HALOPERIDOL | Ki | = | 1.4 | nM | 8.85 |
| CHEMBL10085 | MAZAPERTINE | Ki | = | 2.2 | nM | 8.66 |
| CHEMBL135135 | — | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL134304 | — | Ki | = | 16.0 | nM | 7.80 |
| CHEMBL1161079 | — | Ki | = | 17.0 | nM | 7.77 |
| CHEMBL423712 | — | Ki | = | 20.0 | nM | 7.70 |
| CHEMBL1161087 | — | Ki | = | 22.0 | nM | 7.66 |
| CHEMBL443546 | — | Ki | = | 23.0 | nM | 7.64 |
| CHEMBL275045 | — | Ki | = | 23.0 | nM | 7.64 |
| CHEMBL1161096 | — | Ki | = | 28.0 | nM | 7.55 |
| CHEMBL334767 | — | Ki | = | 31.0 | nM | 7.51 |
| CHEMBL1161088 | — | Ki | = | 31.0 | nM | 7.51 |
| CHEMBL3392290 | — | Ki | = | 32.0 | nM | 7.50 |
| CHEMBL10105 | — | Ki | = | 46.0 | nM | 7.34 |
| CHEMBL135676 | — | Ki | = | 51.0 | nM | 7.29 |
| CHEMBL1161120 | — | Ki | = | 53.0 | nM | 7.28 |
| CHEMBL341402 | — | Ki | = | 56.0 | nM | 7.25 |
| CHEMBL1161083 | — | Ki | = | 57.0 | nM | 7.24 |
| CHEMBL1161076 | — | Ki | = | 63.0 | nM | 7.20 |
| CHEMBL1161078 | — | Ki | = | 65.0 | nM | 7.19 |
| CHEMBL340268 | — | Ki | = | 87.0 | nM | 7.06 |
| CHEMBL135107 | — | Ki | = | 90.0 | nM | 7.05 |
| CHEMBL135938 | — | Ki | = | 90.0 | nM | 7.05 |
| CHEMBL416703 | — | Ki | = | 120.0 | nM | 6.92 |
| CHEMBL135129 | — | Ki | = | 198.0 | nM | 6.70 |
| CHEMBL439607 | — | Ki | = | 302.0 | nM | 6.52 |
| CHEMBL134951 | — | Ki | > | 1000.0 | nM | - |