Assay Detail
Binding
CHEMBL678342
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Tested for Competitive binding inhibition of [3H]spiperone to Dopamine receptor D2 in rat striatal membrane.
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Enhancement of binding of quaternary ammonium derivatives of chlorpromaxine to dopamine D-2 receptors by the addition of a H-bonding group
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 5.94 | 7.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL71 | CHLORPROMAZINE | 4.0 | 1 | 7.30 |
| CHEMBL21564 | — | — | 1 | 6.09 |
| CHEMBL21398 | — | — | 1 | 5.31 |
| CHEMBL279905 | — | — | 1 | 5.07 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL71 | CHLORPROMAZINE | Ki | = | 50.0 | nM | 7.30 |
| CHEMBL21564 | — | Ki | = | 820.0 | nM | 6.09 |
| CHEMBL21398 | — | Ki | = | 4880.0 | nM | 5.31 |
| CHEMBL279905 | — | Ki | = | 8570.0 | nM | 5.07 |