Assay Detail
Binding
CHEMBL678345
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Affinity against striatal dopamine D2 receptors using [3H]spiperone as radioligand in rats.
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Substituted (S)-phenylpiperidines and rigid congeners as preferential dopamine autoreceptor antagonists: synthesis and structure-activity relationships.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 28 | 5.92 | 7.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL94811 | — | — | 1 | 7.10 |
| CHEMBL7549 | PRECLAMOL | 2.0 | 1 | 7.00 |
| CHEMBL93570 | — | — | 1 | 6.99 |
| CHEMBL93646 | — | — | 1 | 6.98 |
| CHEMBL93101 | — | — | 1 | 6.39 |
| CHEMBL96191 | — | — | 1 | 6.21 |
| CHEMBL93383 | — | — | 1 | 6.14 |
| CHEMBL314536 | — | — | 1 | 6.12 |
| CHEMBL413483 | — | — | 1 | 5.98 |
| CHEMBL92183 | — | — | 1 | 5.94 |
| CHEMBL93917 | — | — | 1 | 5.91 |
| CHEMBL93946 | — | — | 1 | 5.78 |
| CHEMBL93212 | — | — | 1 | 5.72 |
| CHEMBL93679 | — | — | 1 | 5.70 |
| CHEMBL93900 | — | — | 1 | 5.66 |
| CHEMBL90798 | — | — | 1 | 5.63 |
| CHEMBL93682 | — | — | 1 | 5.57 |
| CHEMBL328894 | — | — | 1 | 5.51 |
| CHEMBL329443 | — | — | 1 | 5.47 |
| CHEMBL93582 | — | — | 1 | 5.46 |
| CHEMBL93594 | — | — | 1 | 5.38 |
| CHEMBL311730 | — | — | 1 | 5.20 |
| CHEMBL90797 | — | — | 1 | 5.18 |
| CHEMBL90662 | — | — | 1 | 5.08 |
| CHEMBL92939 | — | — | 1 | - |
| CHEMBL92232 | — | — | 1 | - |
| CHEMBL91228 | — | — | 1 | - |
| CHEMBL96726 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL94811 | — | Ki | = | 80.0 | nM | 7.10 |
| CHEMBL7549 | PRECLAMOL | Ki | = | 100.0 | nM | 7.00 |
| CHEMBL93570 | — | Ki | = | 102.0 | nM | 6.99 |
| CHEMBL93646 | — | Ki | = | 105.0 | nM | 6.98 |
| CHEMBL93101 | — | Ki | = | 410.0 | nM | 6.39 |
| CHEMBL96191 | — | Ki | = | 617.0 | nM | 6.21 |
| CHEMBL93383 | — | Ki | = | 717.0 | nM | 6.14 |
| CHEMBL314536 | — | Ki | = | 760.0 | nM | 6.12 |
| CHEMBL413483 | — | Ki | = | 1050.0 | nM | 5.98 |
| CHEMBL92183 | — | Ki | = | 1140.0 | nM | 5.94 |
| CHEMBL93917 | — | Ki | = | 1229.0 | nM | 5.91 |
| CHEMBL93946 | — | Ki | = | 1670.0 | nM | 5.78 |
| CHEMBL93212 | — | Ki | = | 1890.0 | nM | 5.72 |
| CHEMBL93679 | — | Ki | = | 2000.0 | nM | 5.70 |
| CHEMBL93900 | — | Ki | = | 2170.0 | nM | 5.66 |
| CHEMBL90798 | — | Ki | = | 2330.0 | nM | 5.63 |
| CHEMBL93682 | — | Ki | = | 2670.0 | nM | 5.57 |
| CHEMBL328894 | — | Ki | = | 3100.0 | nM | 5.51 |
| CHEMBL329443 | — | Ki | = | 3390.0 | nM | 5.47 |
| CHEMBL93582 | — | Ki | = | 3440.0 | nM | 5.46 |
| CHEMBL93594 | — | Ki | = | 4170.0 | nM | 5.38 |
| CHEMBL311730 | — | Ki | = | 6270.0 | nM | 5.20 |
| CHEMBL90797 | — | Ki | = | 6540.0 | nM | 5.18 |
| CHEMBL90662 | — | Ki | = | 8330.0 | nM | 5.08 |
| CHEMBL92939 | — | Ki | > | 172.0 | nM | - |
| CHEMBL92232 | — | Ki | > | 15000.0 | nM | - |
| CHEMBL91228 | — | Ki | > | 15000.0 | nM | - |
| CHEMBL96726 | — | Ki | > | 172.0 | nM | - |