Assay Detail
Binding
CHEMBL678435
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Compound tested for the inhibition of Gamma-glutamyltranspeptidase in rat kidney at pH 8.0 at 37 degree C (Competitive inhibition)
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Kidney |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Glutathione hydrolase 1 proenzyme (CHEMBL2943) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Synthesis of S-alkyl L-homocysteine analogues of glutathione and their kinetic studies with gamma-glutamyl transpeptidase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 4.28 | 4.28 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL116299 | — | — | 1 | 4.28 |
| CHEMBL42336 | METHIONINE | 3.0 | 1 | - |
| CHEMBL177381 | — | — | 1 | - |
| CHEMBL116811 | — | — | 1 | - |
| CHEMBL445753 | METHIONINE SULFOXIDE | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL116299 | — | Ki | = | 53000.0 | nM | 4.28 |
| CHEMBL42336 | METHIONINE | Ki | = | 26900000.0 | nM | - |
| CHEMBL177381 | — | Ki | = | 520000.0 | nM | - |
| CHEMBL116811 | — | Ki | = | 230000.0 | nM | - |
| CHEMBL445753 | METHIONINE SULFOXIDE | Ki | = | 5900000.0 | nM | - |