Assay Detail
Binding
CHEMBL679551
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Inhibition of EGF-stimulated autophosphorylation of epidermal growth factor receptor in A431 cells
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | A-431 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Tyrosine kinase inhibitors. 15. 4-(Phenylamino)quinazoline and 4-(phenylamino)pyrido[d]pyrimidine acrylamides as irreversible inhibitors of the ATP binding site of the epidermal growth factor receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 8.01 | 8.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL53637 | — | — | 1 | 8.64 |
| CHEMBL430571 | — | — | 1 | 8.38 |
| CHEMBL53690 | — | — | 1 | 8.35 |
| CHEMBL31815 | — | — | 1 | 8.33 |
| CHEMBL52913 | — | — | 1 | 7.28 |
| CHEMBL297968 | — | — | 1 | 7.05 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL53637 | — | IC50 | = | 2.3 | nM | 8.64 |
| CHEMBL430571 | — | IC50 | = | 4.2 | nM | 8.38 |
| CHEMBL53690 | — | IC50 | = | 4.5 | nM | 8.35 |
| CHEMBL31815 | — | IC50 | = | 4.7 | nM | 8.33 |
| CHEMBL52913 | — | IC50 | = | 53.0 | nM | 7.28 |
| CHEMBL297968 | — | IC50 | = | 90.0 | nM | 7.05 |