Compound Detail
CHEMBL53690
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL53690 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | LSYGGBSRDNYACG-UHFFFAOYSA-N |
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
358.3
MW (Da)
4.52
ALogP
4
HBA
2
HBD
66.9
PSA (Ų)
0.67
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 9.04
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Epidermal growth factor receptor CHEMBL203 | IC50 | 9.04 | 8.695 | 0.9 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Epidermal growth factor receptor | IC50 | = | 0.91 | nM | 9.04 | Inhibition of phosphorylation of glutamic acid/tyrosine random copolymer by isol... | 10346932 |
| Epidermal growth factor receptor | IC50 | = | 4.5 | nM | 8.35 | Inhibition of EGF-stimulated autophosphorylation of epidermal growth factor rece... | 10346932 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 10346932 | 10.1021/jm9806603 | Epidermal growth factor receptor | 3 |
Data from ChEMBL 36 via Core Engine