Assay Detail
Binding
CHEMBL856168
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of phosphorylation of glutamic acid/tyrosine random copolymer by isolated epidermal growth factor receptor (EGFR)
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Tyrosine kinase inhibitors. 15. 4-(Phenylamino)quinazoline and 4-(phenylamino)pyrido[d]pyrimidine acrylamides as irreversible inhibitors of the ATP binding site of the epidermal growth factor receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 9.01 | 9.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL52913 | — | — | 1 | 9.60 |
| CHEMBL31815 | — | — | 1 | 9.38 |
| CHEMBL53690 | — | — | 1 | 9.04 |
| CHEMBL297968 | — | — | 1 | 8.80 |
| CHEMBL53637 | — | — | 1 | 8.80 |
| CHEMBL430571 | — | — | 1 | 8.44 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL52913 | — | IC50 | = | 0.25 | nM | 9.60 |
| CHEMBL31815 | — | IC50 | = | 0.42 | nM | 9.38 |
| CHEMBL53690 | — | IC50 | = | 0.91 | nM | 9.04 |
| CHEMBL297968 | — | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL53637 | — | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL430571 | — | IC50 | = | 3.6 | nM | 8.44 |