Assay Detail
Binding
CHEMBL679572
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory activity against Leishmania major Farnesyl diphosphate synthase
43
Total Activities
43
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Leishmania major |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Farnesyl pyrophosphate synthase (CHEMBL3693) ↗| Type | SINGLE PROTEIN |
| Organism | Leishmania donovani |
Publication
Effects of bisphosphonates on the growth of Entamoeba histolytica and Plasmodium species in vitro and in vivo.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 43 | 5.70 | 6.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4303669 | ZOLEDRONIC ACID | 4.0 | 1 | 6.96 |
| CHEMBL56253 | (CYCLOHEXYLAMINO)METHYLENEDIPHOSPHONIC ACID | — | 1 | 6.80 |
| CHEMBL301065 | — | — | 1 | 6.80 |
| CHEMBL923 | RISEDRONIC ACID | 4.0 | 1 | 6.77 |
| CHEMBL294192 | — | — | 1 | 6.77 |
| CHEMBL55464 | — | — | 1 | 6.60 |
| CHEMBL301244 | — | — | 1 | 6.51 |
| CHEMBL56255 | (PENTYLAMINO)METHYLENEDIPHOSPHONIC ACID | — | 1 | 6.46 |
| CHEMBL56011 | — | — | 1 | 6.44 |
| CHEMBL291727 | — | — | 1 | 6.37 |
| CHEMBL53982 | — | — | 1 | 6.35 |
| CHEMBL55988 | — | — | 1 | 6.32 |
| CHEMBL56073 | — | — | 1 | 6.31 |
| CHEMBL54537 | — | — | 1 | 6.30 |
| CHEMBL58830 | (CYCLOPENTYLAMINO)METHYLENEDIPHOSPHONIC ACID | — | 1 | 6.27 |
| CHEMBL55856 | (ISOPENTYLAMINO)METHYLENEDIPHOSPHONIC ACID | — | 1 | 6.08 |
| CHEMBL417549 | (NONYLAMINO)METHYLENEDIPHOSPHONIC ACID | — | 1 | 6.05 |
| CHEMBL52251 | (OCTYLAMINO)METHYLENEDIPHOSPHONIC ACID | — | 1 | 5.97 |
| CHEMBL54480 | — | — | 1 | 5.94 |
| CHEMBL56254 | (HEXYLAMINO)METHYLENEDIPHOSPHONIC ACID | — | 1 | 5.76 |
| CHEMBL54004 | — | — | 1 | 5.62 |
| CHEMBL412889 | (CYCLOOCTYLAMINO)METHYLENEDIPHOSPHONIC ACID | — | 1 | 5.61 |
| CHEMBL298852 | — | — | 1 | 5.47 |
| CHEMBL55264 | — | — | 1 | 5.23 |
| CHEMBL55837 | — | — | 1 | 5.19 |
| CHEMBL54747 | — | — | 1 | 5.17 |
| CHEMBL416301 | — | — | 1 | 5.11 |
| CHEMBL299988 | — | — | 1 | 5.02 |
| CHEMBL431735 | — | — | 1 | 4.97 |
| CHEMBL54344 | (DIETHYLAMINO)METHYLENEDIPHOSPHONIC ACID | — | 1 | 4.74 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4303669 | ZOLEDRONIC ACID | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL56253 | (CYCLOHEXYLAMINO)METHYLENEDIPHOSPHONIC ACID | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL301065 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL923 | RISEDRONIC ACID | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL294192 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL55464 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL301244 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL56255 | (PENTYLAMINO)METHYLENEDIPHOSPHONIC ACID | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL56011 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL291727 | — | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL53982 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL55988 | — | IC50 | = | 480.0 | nM | 6.32 |
| CHEMBL56073 | — | IC50 | = | 490.0 | nM | 6.31 |
| CHEMBL54537 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL58830 | (CYCLOPENTYLAMINO)METHYLENEDIPHOSPHONIC ACID | IC50 | = | 540.0 | nM | 6.27 |
| CHEMBL55856 | (ISOPENTYLAMINO)METHYLENEDIPHOSPHONIC ACID | IC50 | = | 830.0 | nM | 6.08 |
| CHEMBL417549 | (NONYLAMINO)METHYLENEDIPHOSPHONIC ACID | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL52251 | (OCTYLAMINO)METHYLENEDIPHOSPHONIC ACID | IC50 | = | 1060.0 | nM | 5.97 |
| CHEMBL54480 | — | IC50 | = | 1140.0 | nM | 5.94 |
| CHEMBL56254 | (HEXYLAMINO)METHYLENEDIPHOSPHONIC ACID | IC50 | = | 1720.0 | nM | 5.76 |
| CHEMBL54004 | — | IC50 | = | 2370.0 | nM | 5.62 |
| CHEMBL412889 | (CYCLOOCTYLAMINO)METHYLENEDIPHOSPHONIC ACID | IC50 | = | 2440.0 | nM | 5.61 |
| CHEMBL298852 | — | IC50 | = | 3420.0 | nM | 5.47 |
| CHEMBL55264 | — | IC50 | = | 5880.0 | nM | 5.23 |
| CHEMBL55837 | — | IC50 | = | 6500.0 | nM | 5.19 |
| CHEMBL54747 | — | IC50 | = | 6750.0 | nM | 5.17 |
| CHEMBL416301 | — | IC50 | = | 7750.0 | nM | 5.11 |
| CHEMBL299988 | — | IC50 | = | 9600.0 | nM | 5.02 |
| CHEMBL431735 | — | IC50 | = | 10740.0 | nM | 4.97 |
| CHEMBL54344 | (DIETHYLAMINO)METHYLENEDIPHOSPHONIC ACID | IC50 | = | 18200.0 | nM | 4.74 |
| CHEMBL298547 | — | IC50 | = | 19940.0 | nM | 4.70 |
| CHEMBL292224 | (CYCLOPROPYLAMINO)METHYLENEDIPHOSPHONIC ACID | IC50 | = | 40500.0 | nM | 4.39 |
| CHEMBL433833 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL55371 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL56028 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL55810 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL301954 | (DIISOPROPYLAMINO)METHYLENEDIPHOSPHONIC ACID | IC50 | > | 100000.0 | nM | - |
| CHEMBL55359 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL301572 | MORPHOLINOMETHYLENEDIPHOSPHONIC ACID | IC50 | > | 100000.0 | nM | - |
| CHEMBL299491 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL52761 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL300755 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL434978 | — | IC50 | > | 100000.0 | nM | - |