Assay Detail
Binding
CHEMBL679941
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Tested in vitro for the inhibition of [3H]raclopride binding to Dopamine receptor D2 in rat striatum
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Striatum |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
(Dipropylamino)-tetrahydronaphthofurans: centrally acting serotonin agonists and dopamine agonists-antagonists
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 10 | 7.54 | 9.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL273273 | 5-OH-DPAT | — | 1 | 9.15 |
| CHEMBL285755 | — | — | 1 | 8.60 |
| CHEMBL278751 | — | — | 1 | 7.82 |
| CHEMBL96735 | — | — | 1 | 7.75 |
| CHEMBL93186 | — | — | 1 | 7.50 |
| CHEMBL433002 | — | — | 1 | 7.34 |
| CHEMBL314548 | — | — | 1 | 7.19 |
| CHEMBL56 | 8-OH-DPAT | — | 1 | 7.07 |
| CHEMBL328107 | — | — | 1 | 6.82 |
| CHEMBL430332 | — | — | 1 | 6.11 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL273273 | 5-OH-DPAT | Ki | = | 0.7 | nM | 9.15 |
| CHEMBL285755 | — | Ki | = | 2.5 | nM | 8.60 |
| CHEMBL278751 | — | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL96735 | — | Ki | = | 18.0 | nM | 7.75 |
| CHEMBL93186 | — | Ki | = | 32.0 | nM | 7.50 |
| CHEMBL433002 | — | Ki | = | 46.0 | nM | 7.34 |
| CHEMBL314548 | — | Ki | = | 64.0 | nM | 7.19 |
| CHEMBL56 | 8-OH-DPAT | Ki | = | 86.0 | nM | 7.07 |
| CHEMBL328107 | — | Ki | = | 150.0 | nM | 6.82 |
| CHEMBL430332 | — | Ki | = | 769.0 | nM | 6.11 |