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Assay Detail

CHEMBL680042

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Maximum Inhibition of fatty acid amide hydrolase (FAAH) was determined using rat brain homogenates at concentrations ranging from 0.5 to 100 uM
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Tissue Brain
Confidence 8 — Homologous single protein target
Curated By Autocuration

Target

Fatty-acid amide hydrolase 1 (CHEMBL3229)
Type SINGLE PROTEIN
Organism Rattus norvegicus

Publication

Design, synthesis, and biological evaluation of new inhibitors of the endocannabinoid uptake: comparison with effects on fatty acid amidohydrolase.
López-Rodríguez ML, Viso A, Ortega-Gutiérrez S, Fowler CJ, Tiger G, de Lago E, Fernández-Ruiz J, Ramos JA.
J Med Chem (2003) 46 : 1512 -1522
PubMed 12672252 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 1 4.62 4.62

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL41226 1 4.62

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL41226 IC50 = 24000.0 nM 4.62