Assay Detail
Functional
CHEMBL680361
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Muscarinic potency was measured in guinea pig ileum
14
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cavia porcellus |
| Tissue | Ileum |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Conformational studies of muscarone analogues: X-ray analysis and molecular mechanics calculations.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 14 | 7.90 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL105198 | — | — | 2 | 9.00 |
| CHEMBL105457 | — | — | 2 | 8.38 |
| CHEMBL320820 | — | — | 2 | 8.23 |
| CHEMBL321136 | — | — | 2 | 7.95 |
| CHEMBL12587 | MUSCARINE | — | 1 | 7.50 |
| CHEMBL105471 | — | — | 1 | 7.50 |
| CHEMBL430655 | — | — | 2 | 7.38 |
| CHEMBL317886 | — | — | 2 | 6.87 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL105198 | — | EC50 | = | 1.0 | nM | 9.00 |
| CHEMBL105198 | — | EC50 | = | 1.0 | nM | 9.00 |
| CHEMBL105457 | — | EC50 | = | 4.169 | nM | 8.38 |
| CHEMBL105457 | — | EC50 | = | 4.169 | nM | 8.38 |
| CHEMBL320820 | — | EC50 | = | 5.888 | nM | 8.23 |
| CHEMBL320820 | — | EC50 | = | 5.888 | nM | 8.23 |
| CHEMBL321136 | — | EC50 | = | 11.22 | nM | 7.95 |
| CHEMBL321136 | — | EC50 | = | 11.22 | nM | 7.95 |
| CHEMBL12587 | MUSCARINE | EC50 | = | 31.62 | nM | 7.50 |
| CHEMBL105471 | — | EC50 | = | 31.62 | nM | 7.50 |
| CHEMBL430655 | — | EC50 | = | 41.69 | nM | 7.38 |
| CHEMBL430655 | — | EC50 | = | 41.69 | nM | 7.38 |
| CHEMBL317886 | — | EC50 | = | 134.9 | nM | 6.87 |
| CHEMBL317886 | — | EC50 | = | 134.9 | nM | 6.87 |