Assay Detail
Functional
CHEMBL680425
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Tested for the force increase in guinea pig atria
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cavia porcellus |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Discovery and synthesis of methyl 2,5-dimethyl-4-[2- (phenylmethyl)benzoyl]-1H-pyrrole-3-carboxylate (FPL 64176) and analogues: the first examples of a new class of calcium channel activator.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 14 | 5.50 | 7.31 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL93655 | — | — | 1 | 7.31 |
| CHEMBL93689 | — | — | 1 | 6.84 |
| CHEMBL327598 | — | — | 1 | 6.34 |
| CHEMBL1082832 | — | — | 1 | 5.71 |
| CHEMBL93352 | — | — | 1 | 5.68 |
| CHEMBL420064 | — | — | 1 | 5.42 |
| CHEMBL330509 | — | — | 1 | 5.40 |
| CHEMBL93511 | — | — | 1 | 5.32 |
| CHEMBL327915 | — | — | 1 | 5.23 |
| CHEMBL94001 | — | — | 1 | 5.05 |
| CHEMBL316123 | — | — | 1 | 5.02 |
| CHEMBL93404 | — | — | 1 | 4.85 |
| CHEMBL92245 | — | — | 1 | 4.66 |
| CHEMBL327446 | — | — | 1 | 4.16 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL93655 | — | EC50 | = | 49.0 | nM | 7.31 |
| CHEMBL93689 | — | EC50 | = | 144.0 | nM | 6.84 |
| CHEMBL327598 | — | EC50 | = | 460.0 | nM | 6.34 |
| CHEMBL1082832 | — | EC50 | = | 1950.0 | nM | 5.71 |
| CHEMBL93352 | — | EC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL420064 | — | EC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL330509 | — | EC50 | = | 3980.0 | nM | 5.40 |
| CHEMBL93511 | — | EC50 | = | 4840.0 | nM | 5.32 |
| CHEMBL327915 | — | EC50 | = | 5900.0 | nM | 5.23 |
| CHEMBL94001 | — | EC50 | = | 8950.0 | nM | 5.05 |
| CHEMBL316123 | — | EC50 | = | 9470.0 | nM | 5.02 |
| CHEMBL93404 | — | EC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL92245 | — | EC50 | = | 21900.0 | nM | 4.66 |
| CHEMBL327446 | — | EC50 | = | 70000.0 | nM | 4.16 |