Assay Detail
Binding
CHEMBL680442
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of transfer of [3H]FPP to biotin K-ras peptide (KKSKTKCVIM) catalyzed by bovine FTase
36
Total Activities
36
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 6 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Discovery of potent imidazole and cyanophenyl containing farnesyltransferase inhibitors with improved oral bioavailability.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 36 | 8.85 | 9.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL41515 | — | — | 1 | 9.80 |
| CHEMBL41951 | — | — | 1 | 9.74 |
| CHEMBL37194 | — | — | 1 | 9.74 |
| CHEMBL434396 | — | — | 1 | 9.60 |
| CHEMBL38615 | — | — | 1 | 9.40 |
| CHEMBL43631 | — | — | 1 | 9.37 |
| CHEMBL41268 | — | — | 1 | 9.35 |
| CHEMBL39096 | — | — | 1 | 9.29 |
| CHEMBL38941 | — | — | 1 | 9.29 |
| CHEMBL290760 | — | — | 1 | 9.24 |
| CHEMBL43455 | — | — | 1 | 9.21 |
| CHEMBL289844 | — | — | 1 | 9.19 |
| CHEMBL43082 | — | — | 1 | 9.15 |
| CHEMBL288901 | — | — | 1 | 9.14 |
| CHEMBL38616 | — | — | 1 | 9.12 |
| CHEMBL38438 | — | — | 1 | 9.09 |
| CHEMBL288449 | — | — | 1 | 9.08 |
| CHEMBL432477 | — | — | 1 | 9.06 |
| CHEMBL288046 | — | — | 1 | 9.05 |
| CHEMBL39117 | — | — | 1 | 9.04 |
| CHEMBL39805 | — | — | 1 | 9.01 |
| CHEMBL41682 | — | — | 1 | 9.00 |
| CHEMBL41936 | — | — | 1 | 9.00 |
| CHEMBL287729 | — | — | 1 | 8.77 |
| CHEMBL288838 | — | — | 1 | 8.74 |
| CHEMBL290161 | — | — | 1 | 8.72 |
| CHEMBL41454 | — | — | 1 | 8.70 |
| CHEMBL38595 | — | — | 1 | 8.70 |
| CHEMBL41540 | — | — | 1 | 8.41 |
| CHEMBL38974 | — | — | 1 | 8.09 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL41515 | — | IC50 | = | 0.16 | nM | 9.80 |
| CHEMBL41951 | — | IC50 | = | 0.18 | nM | 9.74 |
| CHEMBL37194 | — | IC50 | = | 0.18 | nM | 9.74 |
| CHEMBL434396 | — | IC50 | = | 0.25 | nM | 9.60 |
| CHEMBL38615 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL43631 | — | IC50 | = | 0.43 | nM | 9.37 |
| CHEMBL41268 | — | IC50 | = | 0.45 | nM | 9.35 |
| CHEMBL39096 | — | IC50 | = | 0.51 | nM | 9.29 |
| CHEMBL38941 | — | IC50 | = | 0.51 | nM | 9.29 |
| CHEMBL290760 | — | IC50 | = | 0.57 | nM | 9.24 |
| CHEMBL43455 | — | IC50 | = | 0.62 | nM | 9.21 |
| CHEMBL289844 | — | IC50 | = | 0.64 | nM | 9.19 |
| CHEMBL43082 | — | IC50 | = | 0.71 | nM | 9.15 |
| CHEMBL288901 | — | IC50 | = | 0.73 | nM | 9.14 |
| CHEMBL38616 | — | IC50 | = | 0.75 | nM | 9.12 |
| CHEMBL38438 | — | IC50 | = | 0.82 | nM | 9.09 |
| CHEMBL288449 | — | IC50 | = | 0.84 | nM | 9.08 |
| CHEMBL432477 | — | IC50 | = | 0.88 | nM | 9.06 |
| CHEMBL288046 | — | IC50 | = | 0.9 | nM | 9.05 |
| CHEMBL39117 | — | IC50 | = | 0.92 | nM | 9.04 |
| CHEMBL39805 | — | IC50 | = | 0.98 | nM | 9.01 |
| CHEMBL41682 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL41936 | — | IC50 | = | 0.99 | nM | 9.00 |
| CHEMBL287729 | — | IC50 | = | 1.7 | nM | 8.77 |
| CHEMBL288838 | — | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL290161 | — | IC50 | = | 1.9 | nM | 8.72 |
| CHEMBL38595 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL41454 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL41540 | — | IC50 | = | 3.9 | nM | 8.41 |
| CHEMBL38974 | — | IC50 | = | 8.2 | nM | 8.09 |
| CHEMBL38567 | — | IC50 | = | 8.5 | nM | 8.07 |
| CHEMBL288523 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL418059 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL41518 | — | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL38802 | — | IC50 | = | 58.0 | nM | 7.24 |
| CHEMBL290315 | — | IC50 | = | 68.0 | nM | 7.17 |