Compound Detail
CHEMBL41518
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Cn1cncc1C(OCc1ccc(C#N)nc1N1CCN(C(=O)OC(C)(C)C)CC1)c1ccc(C#N)cc1
Basic Information
| ChEMBL ID | CHEMBL41518 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | BLLWRZKPPHTMHT-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
513.6
MW (Da)
3.92
ALogP
9
HBA
0
HBD
120.3
PSA (Ų)
0.49
QED
1
Ro5 Violations
6
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 7.38
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Geranylgeranyl transferase type-1 subunit beta CHEMBL4135 | IC50 | 7.38 | 7.38 | 42.0 | 1 |
| Protein farnesyltransferase CHEMBL2095178 | IC50 | 7.36 | 7.36 | 44.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Geranylgeranyl transferase type-1 subunit beta | IC50 | = | 42.0 | nM | 7.38 | Inhibition of transfer of [3H]FPP to biotin K-ras peptide (KKSKTKCVIM) catalyzed... | 12699757 |
| Protein farnesyltransferase | IC50 | = | 44.0 | nM | 7.36 | Inhibition of transfer of [3H]FPP to biotin K-ras peptide (KKSKTKCVIM) catalyzed... | 12699757 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 12699757 | 10.1016/s0960-894x(03)00195-1 | Protein farnesyltransferase | 1 |
| 12699757 | 10.1016/s0960-894x(03)00195-1 | Geranylgeranyl transferase type-1 subunit beta | 1 |
Data from ChEMBL 36 via Core Engine