Assay Detail
Functional
CHEMBL681033
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Stimulation of amylase release in guinea pig pancreas
56
Total Activities
56
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cavia porcellus |
| Tissue | Pancreas |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Development of potent and selective CCK-A receptor agonists from Boc-CCK-4: tetrapeptides containing Lys(N epsilon)-amide residues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 56 | 7.30 | 9.41 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL156559 | — | — | 1 | 9.41 |
| CHEMBL292298 | — | — | 1 | 8.64 |
| CHEMBL413768 | — | — | 1 | 8.62 |
| CHEMBL387073 | — | — | 1 | 8.54 |
| CHEMBL433640 | — | — | 1 | 8.52 |
| CHEMBL278447 | — | — | 1 | 8.46 |
| CHEMBL62345 | — | — | 1 | 8.46 |
| CHEMBL3144536 | — | — | 1 | 8.41 |
| CHEMBL292519 | — | — | 1 | 8.40 |
| CHEMBL3144564 | — | — | 1 | 8.14 |
| CHEMBL60385 | — | — | 1 | 8.07 |
| CHEMBL62887 | — | — | 1 | 7.96 |
| CHEMBL3144542 | — | — | 1 | 7.85 |
| CHEMBL3144553 | — | — | 1 | 7.80 |
| CHEMBL302911 | — | — | 1 | 7.80 |
| CHEMBL3144548 | — | — | 1 | 7.77 |
| CHEMBL3144561 | — | — | 1 | 7.77 |
| CHEMBL3144554 | — | — | 1 | 7.70 |
| CHEMBL292471 | — | — | 1 | 7.70 |
| CHEMBL292490 | — | — | 1 | 7.70 |
| CHEMBL3144565 | — | — | 1 | 7.60 |
| CHEMBL3144560 | — | — | 1 | 7.57 |
| CHEMBL292071 | — | — | 1 | 7.55 |
| CHEMBL294542 | — | — | 1 | 7.54 |
| CHEMBL294304 | — | — | 1 | 7.52 |
| CHEMBL3144539 | — | — | 1 | 7.52 |
| CHEMBL303994 | — | — | 1 | 7.50 |
| CHEMBL413548 | — | — | 1 | 7.42 |
| CHEMBL3144562 | — | — | 1 | 7.42 |
| CHEMBL418123 | — | — | 1 | 7.41 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL156559 | — | EC50 | = | 0.39 | nM | 9.41 |
| CHEMBL292298 | — | EC50 | = | 2.3 | nM | 8.64 |
| CHEMBL413768 | — | EC50 | = | 2.4 | nM | 8.62 |
| CHEMBL387073 | — | EC50 | = | 2.9 | nM | 8.54 |
| CHEMBL433640 | — | EC50 | = | 3.0 | nM | 8.52 |
| CHEMBL278447 | — | EC50 | = | 3.5 | nM | 8.46 |
| CHEMBL62345 | — | EC50 | = | 3.5 | nM | 8.46 |
| CHEMBL3144536 | — | EC50 | = | 3.9 | nM | 8.41 |
| CHEMBL292519 | — | EC50 | = | 4.0 | nM | 8.40 |
| CHEMBL3144564 | — | EC50 | = | 7.2 | nM | 8.14 |
| CHEMBL60385 | — | EC50 | = | 8.6 | nM | 8.07 |
| CHEMBL62887 | — | EC50 | = | 11.0 | nM | 7.96 |
| CHEMBL3144542 | — | EC50 | = | 14.0 | nM | 7.85 |
| CHEMBL3144553 | — | EC50 | = | 16.0 | nM | 7.80 |
| CHEMBL302911 | — | EC50 | = | 16.0 | nM | 7.80 |
| CHEMBL3144548 | — | EC50 | = | 17.0 | nM | 7.77 |
| CHEMBL3144561 | — | EC50 | = | 17.0 | nM | 7.77 |
| CHEMBL3144554 | — | EC50 | = | 20.0 | nM | 7.70 |
| CHEMBL292471 | — | EC50 | = | 20.0 | nM | 7.70 |
| CHEMBL292490 | — | EC50 | = | 20.0 | nM | 7.70 |
| CHEMBL3144565 | — | EC50 | = | 25.0 | nM | 7.60 |
| CHEMBL3144560 | — | EC50 | = | 27.0 | nM | 7.57 |
| CHEMBL292071 | — | EC50 | = | 28.0 | nM | 7.55 |
| CHEMBL294542 | — | EC50 | = | 29.0 | nM | 7.54 |
| CHEMBL3144539 | — | EC50 | = | 30.0 | nM | 7.52 |
| CHEMBL294304 | — | EC50 | = | 30.0 | nM | 7.52 |
| CHEMBL303994 | — | EC50 | = | 32.0 | nM | 7.50 |
| CHEMBL413548 | — | EC50 | = | 38.0 | nM | 7.42 |
| CHEMBL3144562 | — | EC50 | = | 38.0 | nM | 7.42 |
| CHEMBL418123 | — | EC50 | = | 39.0 | nM | 7.41 |
| CHEMBL3144551 | — | EC50 | = | 45.0 | nM | 7.35 |
| CHEMBL3144550 | — | EC50 | = | 46.0 | nM | 7.34 |
| CHEMBL3144563 | — | EC50 | = | 52.0 | nM | 7.28 |
| CHEMBL3144552 | — | EC50 | = | 55.0 | nM | 7.26 |
| CHEMBL3144537 | — | EC50 | = | 59.0 | nM | 7.23 |
| CHEMBL418500 | — | EC50 | = | 62.0 | nM | 7.21 |
| CHEMBL293026 | — | EC50 | = | 68.0 | nM | 7.17 |
| CHEMBL3144535 | — | EC50 | = | 69.0 | nM | 7.16 |
| CHEMBL3144540 | — | EC50 | = | 74.0 | nM | 7.13 |
| CHEMBL59404 | — | EC50 | = | 79.0 | nM | 7.10 |
| CHEMBL3144555 | — | EC50 | = | 79.0 | nM | 7.10 |
| CHEMBL3144549 | — | EC50 | = | 90.0 | nM | 7.05 |
| CHEMBL3144567 | — | EC50 | = | 92.0 | nM | 7.04 |
| CHEMBL3144566 | — | EC50 | = | 98.0 | nM | 7.01 |
| CHEMBL3144534 | — | EC50 | = | 160.0 | nM | 6.80 |
| CHEMBL3144533 | — | EC50 | = | 170.0 | nM | 6.77 |
| CHEMBL3144538 | — | EC50 | = | 210.0 | nM | 6.68 |
| CHEMBL3144544 | — | EC50 | = | 240.0 | nM | 6.62 |
| CHEMBL3144543 | — | EC50 | = | 300.0 | nM | 6.52 |
| CHEMBL3144546 | — | EC50 | = | 450.0 | nM | 6.35 |