Assay Detail
Binding
CHEMBL681410
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In vitro concentration required to reduce Farnesyltransferase catalyzed incorporation of [3H]FPP into recombinant Ha-Ras protein by 50%
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 6 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Pseudodipeptide inhibitors of protein farnesyltransferase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 26 | 6.35 | 7.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL128967 | — | — | 1 | 7.64 |
| CHEMBL132155 | — | — | 1 | 7.40 |
| CHEMBL129140 | — | — | 1 | 7.34 |
| CHEMBL340735 | — | — | 1 | 7.22 |
| CHEMBL129718 | — | — | 1 | 7.16 |
| CHEMBL129603 | — | — | 1 | 7.01 |
| CHEMBL129589 | — | — | 1 | 6.92 |
| CHEMBL433854 | — | — | 1 | 6.46 |
| CHEMBL128448 | — | — | 1 | 6.43 |
| CHEMBL129723 | — | — | 1 | 6.40 |
| CHEMBL338527 | — | — | 1 | 6.35 |
| CHEMBL128937 | — | — | 1 | 6.22 |
| CHEMBL128611 | — | — | 1 | 6.18 |
| CHEMBL130769 | — | — | 1 | 6.15 |
| CHEMBL340960 | — | — | 1 | 6.05 |
| CHEMBL339731 | — | — | 1 | 6.03 |
| CHEMBL129175 | — | — | 1 | 6.00 |
| CHEMBL2370669 | — | — | 1 | 6.00 |
| CHEMBL129110 | — | — | 1 | 5.96 |
| CHEMBL339824 | — | — | 1 | 5.89 |
| CHEMBL127610 | — | — | 1 | 5.70 |
| CHEMBL129109 | — | — | 1 | 5.55 |
| CHEMBL131001 | — | — | 1 | 5.22 |
| CHEMBL128898 | — | — | 1 | 5.05 |
| CHEMBL337477 | — | — | 1 | - |
| CHEMBL129116 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL128967 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL132155 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL129140 | — | IC50 | = | 46.0 | nM | 7.34 |
| CHEMBL340735 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL129718 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL129603 | — | IC50 | = | 97.0 | nM | 7.01 |
| CHEMBL129589 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL433854 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL128448 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL129723 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL338527 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL128937 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL128611 | — | IC50 | = | 660.0 | nM | 6.18 |
| CHEMBL130769 | — | IC50 | = | 707.0 | nM | 6.15 |
| CHEMBL340960 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL339731 | — | IC50 | = | 945.0 | nM | 6.03 |
| CHEMBL129175 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL2370669 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL129110 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL339824 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL127610 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL129109 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL131001 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL128898 | — | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL337477 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL129116 | — | IC50 | > | 10000.0 | nM | - |