Compound Detail
CHEMBL131001
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Basic Information
| ChEMBL ID | CHEMBL131001 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | IUWJCQWIJMVQAA-VNCLPFQGSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
309.5
MW (Da)
2.08
ALogP
4
HBA
4
HBD
50.1
PSA (Ų)
0.37
QED
0
Ro5 Violations
11
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 5.22
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Protein farnesyltransferase CHEMBL2095178 | IC50 | 5.22 | 5.22 | 6000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Protein farnesyltransferase | IC50 | = | 6000.0 | nM | 5.22 | In vitro concentration required to reduce Farnesyltransferase catalyzed incorpor... | 7562930 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 7562930 | 10.1021/jm00020a010 | Protein farnesyltransferase | 1 |
| 7562930 | 10.1021/jm00020a010 | NIH3T3 | 1 |
Data from ChEMBL 36 via Core Engine