Assay Detail
Binding
CHEMBL681673
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In vitro inhibition of geranylgeranyltransferase.
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bos taurus |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Novel and selective imidazole-containing biphenyl inhibitors of protein farnesyltransferase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 6.28 | 6.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL27843 | — | — | 1 | 6.82 |
| CHEMBL28970 | — | — | 1 | 6.75 |
| CHEMBL431884 | — | — | 1 | 6.64 |
| CHEMBL28588 | — | — | 1 | 6.51 |
| CHEMBL282959 | — | — | 1 | 6.19 |
| CHEMBL28770 | — | — | 1 | 6.00 |
| CHEMBL284448 | — | — | 1 | 6.00 |
| CHEMBL28707 | — | — | 1 | 5.92 |
| CHEMBL28490 | — | — | 1 | 5.72 |
| CHEMBL28659 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL27843 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL28970 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL431884 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL28588 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL282959 | — | IC50 | = | 650.0 | nM | 6.19 |
| CHEMBL28770 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL284448 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL28707 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL28490 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL28659 | — | IC50 | - | nM | - |