Compound Detail
CHEMBL28970
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Basic Information
| ChEMBL ID | CHEMBL28970 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | CVCCWHNZLSJYQW-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
420.6
MW (Da)
6.45
ALogP
4
HBA
0
HBD
44.9
PSA (Ų)
0.37
QED
1
Ro5 Violations
5
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 8.72
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Protein farnesyltransferase CHEMBL2095178 | IC50 | 8.72 | 8.72 | 1.9 | 1 |
| Geranylgeranyl transferase type I CHEMBL2096987 | IC50 | 6.75 | 6.75 | 180.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Protein farnesyltransferase | IC50 | = | 1.9 | nM | 8.72 | In vitro inhibitory activity against farnesyltransferase (FTase) | 12657284 |
| Geranylgeranyl transferase type I | IC50 | = | 180.0 | nM | 6.75 | In vitro inhibition of geranylgeranyltransferase. | 12657284 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 12657284 | 10.1016/s0960-894x(03)00096-9 | Protein farnesyltransferase | 1 |
| 12657284 | 10.1016/s0960-894x(03)00096-9 | Geranylgeranyl transferase type I | 1 |
Data from ChEMBL 36 via Core Engine