Assay Detail
Functional
CHEMBL681784
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Inhibitory potency evaluated against electrically evoked contractions of guinea pig ileum
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cavia porcellus |
| Tissue | Ileum |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Development of conformationally constrained linear peptides exhibiting a high affinity and pronounced selectivity for delta opioid receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 5.98 | 7.08 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL57776 | — | — | 1 | 7.08 |
| CHEMBL299029 | — | — | 1 | 6.70 |
| CHEMBL13786 | — | — | 1 | 6.70 |
| CHEMBL55498 | — | — | 1 | 6.69 |
| CHEMBL124283 | — | — | 1 | 6.39 |
| CHEMBL55734 | — | — | 1 | 6.34 |
| CHEMBL298972 | — | — | 1 | 5.75 |
| CHEMBL56933 | — | — | 1 | 5.55 |
| CHEMBL31421 | — | — | 1 | 5.00 |
| CHEMBL56394 | — | — | 1 | 4.94 |
| CHEMBL301702 | — | — | 1 | 4.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL57776 | — | IC50 | = | 83.3 | nM | 7.08 |
| CHEMBL299029 | — | IC50 | = | 202.0 | nM | 6.70 |
| CHEMBL13786 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL55498 | — | IC50 | = | 204.0 | nM | 6.69 |
| CHEMBL124283 | — | IC50 | = | 406.0 | nM | 6.39 |
| CHEMBL55734 | — | IC50 | = | 460.0 | nM | 6.34 |
| CHEMBL298972 | — | IC50 | = | 1795.0 | nM | 5.75 |
| CHEMBL56933 | — | IC50 | = | 2790.0 | nM | 5.55 |
| CHEMBL31421 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL56394 | — | IC50 | = | 11366.0 | nM | 4.94 |
| CHEMBL301702 | — | IC50 | = | 25250.0 | nM | 4.60 |