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Assay Detail

CHEMBL682008

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of Factor Xa
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Expert

Target

Coagulation factor X (CHEMBL244)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Bisbenzamidine isoxazoline derivatives as factor Xa inhibitors
Quan M, Pruitt J, Ellis C, Liauw A, Galemmo R, Stouten P, Wityak J, Knabb R, Thoolen M, Wong P, Wexler R
Bioorg Med Chem Lett (1997) 7 : 2813 -2818
· DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 13 6.26 7.75

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL96879 1 7.75
CHEMBL19902 DX-9065A 1 7.39
CHEMBL92988 1 7.03
CHEMBL94761 1 6.93
CHEMBL433351 1 6.84
CHEMBL93657 1 6.57
CHEMBL93445 1 6.10
CHEMBL317590 1 6.06
CHEMBL97842 1 5.85
CHEMBL94799 1 5.77
CHEMBL94563 1 5.75
CHEMBL94336 1 4.89
CHEMBL97570 1 4.42

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL96879 Ki = 18.0 nM 7.75
CHEMBL19902 DX-9065A Ki = 41.0 nM 7.39
CHEMBL92988 Ki = 94.0 nM 7.03
CHEMBL94761 Ki = 117.0 nM 6.93
CHEMBL433351 Ki = 143.0 nM 6.84
CHEMBL93657 Ki = 270.0 nM 6.57
CHEMBL93445 Ki = 800.0 nM 6.10
CHEMBL317590 Ki = 870.0 nM 6.06
CHEMBL97842 Ki = 1400.0 nM 5.85
CHEMBL94799 Ki = 1700.0 nM 5.77
CHEMBL94563 Ki = 1800.0 nM 5.75
CHEMBL94336 Ki = 13000.0 nM 4.89
CHEMBL97570 Ki = 38500.0 nM 4.42