Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL682517

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Inhibition of electrically evoked contractions in Guinea pig ileum
17
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Cavia porcellus
Tissue Ileum
Confidence 9 — Direct single protein target
Curated By Expert

Target

Mu-type opioid receptor (CHEMBL4354)
Type SINGLE PROTEIN
Organism Cavia porcellus

Publication

Conformationally restricted deltorphin analogues.
Schiller PW, Weltrowska G, Nguyen TM, Wilkes BC, Chung NN, Lemieux C.
J Med Chem (1992) 35 : 3956 -3961
PubMed 1331451 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 17 6.13 7.44

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL63407 1 7.44
CHEMBL132164 1 6.99
CHEMBL436590 1 6.62
CHEMBL8234 ENKEPHALIN 1 6.61
CHEMBL129815 1 6.60
CHEMBL20775 DELTORPHIN A 2 6.55
CHEMBL124435 1 6.54
CHEMBL338466 1 6.42
CHEMBL317956 DELTORPHIN C 1 6.07
CHEMBL124941 2 5.86
CHEMBL338985 1 5.41
CHEMBL337898 1 4.92
CHEMBL330991 1 4.84
CHEMBL339089 1 -
CHEMBL262312 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL63407 IC50 = 36.2 nM 7.44
CHEMBL132164 IC50 = 102.0 nM 6.99
CHEMBL436590 IC50 = 241.0 nM 6.62
CHEMBL8234 ENKEPHALIN IC50 = 246.0 nM 6.61
CHEMBL129815 IC50 = 251.0 nM 6.60
CHEMBL20775 DELTORPHIN A IC50 = 281.0 nM 6.55
CHEMBL124435 IC50 = 290.0 nM 6.54
CHEMBL338466 IC50 = 380.0 nM 6.42
CHEMBL317956 DELTORPHIN C IC50 = 854.0 nM 6.07
CHEMBL124941 IC50 = 1380.0 nM 5.86
CHEMBL124941 IC50 = 1820.0 nM 5.74
CHEMBL338985 IC50 = 3880.0 nM 5.41
CHEMBL20775 DELTORPHIN A IC50 = 4420.0 nM 5.36
CHEMBL337898 IC50 = 11900.0 nM 4.92
CHEMBL330991 IC50 = 14500.0 nM 4.84
CHEMBL339089 IC50 > 65000.0 nM -
CHEMBL262312 IC50 > 10000.0 nM -