Assay Detail
Functional
CHEMBL683405
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Equilibrium dissociation constant of the compound-receptor complex was determined by its ability to antagonize carbachol-induced contractions in the ileum (spasmolytic activity)
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cavia porcellus |
| Tissue | Ileum |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Conformationally restricted analogues of the muscarinic agent N-methyl-N-(1-methyl-4-pyrrolidino-2-butynyl)acetamide.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 6 | 5.78 | 6.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL310852 | — | — | 1 | 6.62 |
| CHEMBL348504 | — | — | 1 | 6.55 |
| CHEMBL110892 | — | — | 1 | 5.85 |
| CHEMBL354685 | — | — | 1 | 5.84 |
| CHEMBL424383 | — | — | 1 | 4.02 |
| CHEMBL167892 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL310852 | — | Kd | = | 240.0 | nM | 6.62 |
| CHEMBL348504 | — | Kd | = | 280.0 | nM | 6.55 |
| CHEMBL110892 | — | Kd | = | 1400.0 | nM | 5.85 |
| CHEMBL354685 | — | Kd | = | 1430.0 | nM | 5.84 |
| CHEMBL424383 | — | Kd | = | 95600.0 | nM | 4.02 |
| CHEMBL167892 | — | Kd | = | 496000.0 | nM | - |