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Assay Detail

CHEMBL683424

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibitory constant against Fatty-acid amide hydrolase (FAAH) in rat liver
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Tissue Liver
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Fatty-acid amide hydrolase 1 (CHEMBL3229)
Type SINGLE PROTEIN
Organism Rattus norvegicus

Publication

Trifluoromethyl ketone inhibitors of fatty acid amide hydrolase: a probe of structural and conformational features contributing to inhibition.
Boger DL, Sato H, Lerner AE, Austin BJ, Patterson JE, Patricelli MP, Cravatt BF.
Bioorg Med Chem Lett (1999) 9 : 265 -270
PubMed 10021942 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 23 6.35 7.60

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL91417 1 7.60
CHEMBL422064 1 7.09
CHEMBL91077 1 7.02
CHEMBL91416 1 7.00
CHEMBL90258 1 6.89
CHEMBL90308 1 6.85
CHEMBL330520 1 6.85
CHEMBL329187 1 6.77
CHEMBL413727 1 6.77
CHEMBL89946 1 6.62
CHEMBL446934 1 6.50
CHEMBL328734 1 6.36
CHEMBL89508 1 6.31
CHEMBL91352 1 6.24
CHEMBL93880 1 6.11
CHEMBL420429 1 5.92
CHEMBL93675 1 5.92
CHEMBL91592 1 5.55
CHEMBL91076 1 5.36
CHEMBL90719 1 4.97
CHEMBL92681 1 4.57
CHEMBL92219 1 -
CHEMBL327389 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL91417 Ki = 25.0 nM 7.60
CHEMBL422064 Ki = 82.0 nM 7.09
CHEMBL91077 Ki = 96.0 nM 7.02
CHEMBL91416 Ki = 100.0 nM 7.00
CHEMBL90258 Ki = 130.0 nM 6.89
CHEMBL90308 Ki = 140.0 nM 6.85
CHEMBL330520 Ki = 140.0 nM 6.85
CHEMBL329187 Ki = 170.0 nM 6.77
CHEMBL413727 Ki = 170.0 nM 6.77
CHEMBL89946 Ki = 240.0 nM 6.62
CHEMBL446934 Ki = 320.0 nM 6.50
CHEMBL328734 Ki = 440.0 nM 6.36
CHEMBL89508 Ki = 490.0 nM 6.31
CHEMBL91352 Ki = 570.0 nM 6.24
CHEMBL93880 Ki = 780.0 nM 6.11
CHEMBL420429 Ki = 1200.0 nM 5.92
CHEMBL93675 Ki = 1200.0 nM 5.92
CHEMBL91592 Ki = 2800.0 nM 5.55
CHEMBL91076 Ki = 4400.0 nM 5.36
CHEMBL90719 Ki = 10700.0 nM 4.97
CHEMBL92681 Ki = 26900.0 nM 4.57
CHEMBL92219 Ki > 100000.0 nM -
CHEMBL327389 Ki > 100000.0 nM -