Compound Detail
CHEMBL328734
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Basic Information
| ChEMBL ID | CHEMBL328734 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | KFBUHNDQDVQDGC-GJZGRUSLSA-N |
1
Targets
2
Activities
2
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
336.4
MW (Da)
4.31
ALogP
3
HBA
0
HBD
35.5
PSA (Ų)
0.42
QED
0
Ro5 Violations
11
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 5.62
Ki 1 meas. best 6.36
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Fatty-acid amide hydrolase 1 CHEMBL3229 | Ki | 6.36 | 6.36 | 440.0 | 1 |
| Fatty-acid amide hydrolase 1 CHEMBL3229 | IC50 | 5.62 | 5.62 | 2400.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Fatty-acid amide hydrolase 1 | Ki | = | 440.0 | nM | 6.36 | Inhibitory constant against Fatty-acid amide hydrolase (FAAH) in rat liver | 10021942 |
| Fatty-acid amide hydrolase 1 | IC50 | = | 2400.0 | nM | 5.62 | Inhibitory concentration against Fatty-acid amide hydrolase (FAAH) in rat liver | 10021942 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 10021942 | 10.1016/s0960-894x(98)00734-3 | Fatty-acid amide hydrolase 1 | 2 |
Data from ChEMBL 36 via Core Engine