Assay Detail
Binding
CHEMBL683431
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Inhibitory activity against fatty acid amide hydrolase (FAAH)
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
alpha-Keto heterocycle inhibitors of fatty acid amide hydrolase: carbonyl group modification and alpha-substitution.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 13 | 6.21 | 8.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL35925 | — | — | 1 | 8.64 |
| CHEMBL36614 | — | — | 1 | 8.04 |
| CHEMBL39412 | — | — | 1 | 7.00 |
| CHEMBL285678 | — | — | 1 | 6.82 |
| CHEMBL39306 | — | — | 1 | 6.26 |
| CHEMBL37044 | — | — | 1 | 5.85 |
| CHEMBL37585 | — | — | 1 | 5.82 |
| CHEMBL36990 | — | — | 1 | 5.75 |
| CHEMBL40025 | — | — | 1 | 5.70 |
| CHEMBL290997 | — | — | 1 | 5.35 |
| CHEMBL36655 | — | — | 1 | 4.85 |
| CHEMBL418242 | — | — | 1 | 4.43 |
| CHEMBL39796 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL35925 | — | Ki | = | 2.3 | nM | 8.64 |
| CHEMBL36614 | — | Ki | = | 9.1 | nM | 8.04 |
| CHEMBL39412 | — | Ki | = | 100.0 | nM | 7.00 |
| CHEMBL285678 | — | Ki | = | 150.0 | nM | 6.82 |
| CHEMBL39306 | — | Ki | = | 550.0 | nM | 6.26 |
| CHEMBL37044 | — | Ki | = | 1400.0 | nM | 5.85 |
| CHEMBL37585 | — | Ki | = | 1500.0 | nM | 5.82 |
| CHEMBL36990 | — | Ki | = | 1800.0 | nM | 5.75 |
| CHEMBL40025 | — | Ki | = | 2000.0 | nM | 5.70 |
| CHEMBL290997 | — | Ki | = | 4500.0 | nM | 5.35 |
| CHEMBL36655 | — | Ki | = | 14200.0 | nM | 4.85 |
| CHEMBL418242 | — | Ki | = | 37100.0 | nM | 4.43 |
| CHEMBL39796 | — | Ki | > | 100000.0 | nM | - |