Assay Detail
Binding
CHEMBL683492
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Geranylgeranyl transferase type I, an enzyme that recognizes CaaX sequences containing leucine as the terminal residue.
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bos taurus |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Publication
DIARYLETHER INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.39 | 5.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL26149 | — | — | 1 | 5.64 |
| CHEMBL26255 | — | — | 1 | 5.30 |
| CHEMBL25734 | — | — | 1 | 5.24 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL26149 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL26255 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL25734 | — | IC50 | = | 5800.0 | nM | 5.24 |