Compound Detail
CHEMBL25734
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Basic Information
| ChEMBL ID | CHEMBL25734 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | PTYARAMVADWAJN-GFCCVEGCSA-N |
2
Targets
3
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names
Molecular Properties
318.4
MW (Da)
2.85
ALogP
5
HBA
4
HBD
84.6
PSA (Ų)
0.59
QED
0
Ro5 Violations
7
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 3 meas. best 6.6
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Protein farnesyltransferase CHEMBL2095178 | IC50 | 6.6 | 6.6 | 250.0 | 1 |
| Geranylgeranyl transferase type I CHEMBL2096987 | IC50 | 5.24 | 5.24 | 5800.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Protein farnesyltransferase | IC50 | = | 250.0 | nM | 6.6 | Inhibition of the Farnesyltransferase catalyzed incorporation of [3H]FPP into re... | - |
| Geranylgeranyl transferase type I | IC50 | = | 5800.0 | nM | 5.24 | Inhibition of Geranylgeranyl transferase type I, an enzyme that recognizes CaaX ... | - |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| - | 10.1016/S0960-894X(97)00225-4 | Rat1 | 2 |
| 10612589 | 10.1016/s0960-894x(99)00605-8 | Protein farnesyltransferase | 1 |
| - | 10.1016/S0960-894X(97)00225-4 | Protein farnesyltransferase | 1 |
| - | 10.1016/S0960-894X(97)00225-4 | Geranylgeranyl transferase type I | 1 |
Data from ChEMBL 36 via Core Engine