Assay Detail
Binding
CHEMBL683536
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In vitro inhibitory activity against Geranylgeranyl transferase type I
41
Total Activities
41
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 6 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Geranylgeranyl transferase type I (CHEMBL2095164) ↗| Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
Publication
Pyridone-containing farnesyltransferase inhibitors: synthesis and biological evaluation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 41 | 5.91 | 7.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL128371 | — | — | 1 | 7.52 |
| CHEMBL132283 | — | — | 1 | 7.03 |
| CHEMBL128018 | — | — | 1 | 6.96 |
| CHEMBL129578 | — | — | 1 | 6.92 |
| CHEMBL128454 | — | — | 1 | 6.82 |
| CHEMBL338695 | — | — | 1 | 6.80 |
| CHEMBL130062 | — | — | 1 | 6.72 |
| CHEMBL339758 | — | — | 1 | 6.66 |
| CHEMBL335180 | — | — | 1 | 6.54 |
| CHEMBL339801 | — | — | 1 | 6.21 |
| CHEMBL128116 | — | — | 1 | 6.09 |
| CHEMBL130723 | — | — | 1 | 6.05 |
| CHEMBL336168 | — | — | 1 | 5.98 |
| CHEMBL127898 | — | — | 1 | 5.85 |
| CHEMBL336569 | — | — | 1 | 5.82 |
| CHEMBL336497 | — | — | 1 | 5.82 |
| CHEMBL131081 | — | — | 1 | 5.77 |
| CHEMBL131609 | — | — | 1 | 5.75 |
| CHEMBL132337 | — | — | 1 | 5.72 |
| CHEMBL128760 | — | — | 1 | 5.70 |
| CHEMBL131612 | — | — | 1 | 5.64 |
| CHEMBL131108 | — | — | 1 | 5.60 |
| CHEMBL128309 | — | — | 1 | 5.57 |
| CHEMBL128897 | — | — | 1 | 5.54 |
| CHEMBL128501 | — | — | 1 | 5.52 |
| CHEMBL128834 | — | — | 1 | 5.50 |
| CHEMBL130185 | — | — | 1 | 5.48 |
| CHEMBL128282 | — | — | 1 | 5.48 |
| CHEMBL424448 | — | — | 1 | 5.47 |
| CHEMBL274954 | — | — | 1 | 5.47 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL128371 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL132283 | — | IC50 | = | 94.0 | nM | 7.03 |
| CHEMBL128018 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL129578 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL128454 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL338695 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL130062 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL339758 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL335180 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL339801 | — | IC50 | = | 610.0 | nM | 6.21 |
| CHEMBL128116 | — | IC50 | = | 820.0 | nM | 6.09 |
| CHEMBL130723 | — | IC50 | = | 890.0 | nM | 6.05 |
| CHEMBL336168 | — | IC50 | = | 1045.0 | nM | 5.98 |
| CHEMBL127898 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL336497 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL336569 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL131081 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL131609 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL132337 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL128760 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL131612 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL131108 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL128309 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL128897 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL128501 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL128834 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL130185 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL128282 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL424448 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL274954 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL334651 | — | IC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL128267 | — | IC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL131170 | — | IC50 | = | 6200.0 | nM | 5.21 |
| CHEMBL129685 | — | IC50 | = | 7500.0 | nM | 5.12 |
| CHEMBL338349 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL334490 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL131000 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL131116 | — | IC50 | > | 900.0 | nM | - |
| CHEMBL128572 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL128571 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL128573 | — | IC50 | > | 10000.0 | nM | - |