Compound Detail
CHEMBL128116
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Basic Information
| ChEMBL ID | CHEMBL128116 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | HYDRIOWWHJJSSW-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
2
PK Parameters
4
Publications
0
Known Names
Molecular Properties
455.9
MW (Da)
4.89
ALogP
7
HBA
1
HBD
107.8
PSA (Ų)
0.44
QED
0
Ro5 Violations
6
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 9.07
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Protein farnesyltransferase CHEMBL2094108 | IC50 | 9.07 | 9.07 | 0.8 | 1 |
| Geranylgeranyl transferase type I CHEMBL2095164 | IC50 | 6.09 | 6.09 | 820.0 | 1 |
Pharmacokinetic Data
| Parameter | Value | Units | Species |
|---|---|---|---|
| F | - | % | Canis lupus familiaris |
| F | - | % | Cercopithecidae |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Protein farnesyltransferase | IC50 | = | 0.85 | nM | 9.07 | In vitro inhibitory activity against farnesyltransferase (FT) | 14592494 |
| Geranylgeranyl transferase type I | IC50 | = | 820.0 | nM | 6.09 | In vitro inhibitory activity against Geranylgeranyl transferase type I | 14592494 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 14592494 | 10.1016/j.bmcl.2003.08.058 | Protein farnesyltransferase | 2 |
| 14592494 | 10.1016/j.bmcl.2003.08.058 | Geranylgeranyl transferase type I | 1 |
| 14592494 | 10.1016/j.bmcl.2003.08.058 | Canis familiaris | 1 |
| 14592494 | 10.1016/j.bmcl.2003.08.058 | ADMET | 1 |
Data from ChEMBL 36 via Core Engine