Assay Detail
Functional
CHEMBL683596
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Ability to inhibit the electrically evoked contraction of the guinea pig ileum
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cavia porcellus |
| Tissue | Ileum |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Design, synthesis, and biological activities of cyclic lactam peptide analogues of dynorphine A(1-11)-NH2.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 5.99 | 8.97 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL216640 | — | — | 1 | 8.97 |
| CHEMBL217049 | — | — | 1 | 7.85 |
| CHEMBL264733 | — | — | 1 | 6.31 |
| CHEMBL216182 | — | — | 1 | 6.22 |
| CHEMBL413011 | — | — | 1 | 6.21 |
| CHEMBL386170 | — | — | 1 | 5.82 |
| CHEMBL387083 | — | — | 1 | 5.60 |
| CHEMBL384485 | — | — | 1 | 5.50 |
| CHEMBL412580 | — | — | 1 | 5.38 |
| CHEMBL277132 | — | — | 1 | 5.31 |
| CHEMBL412600 | — | — | 1 | 5.03 |
| CHEMBL387437 | — | — | 1 | 4.88 |
| CHEMBL415339 | — | — | 1 | 4.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL216640 | — | IC50 | = | 1.07 | nM | 8.97 |
| CHEMBL217049 | — | IC50 | = | 14.2 | nM | 7.85 |
| CHEMBL264733 | — | IC50 | = | 490.0 | nM | 6.31 |
| CHEMBL216182 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL413011 | — | IC50 | = | 610.0 | nM | 6.21 |
| CHEMBL386170 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL387083 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL384485 | — | IC50 | = | 3170.0 | nM | 5.50 |
| CHEMBL412580 | — | IC50 | = | 4160.0 | nM | 5.38 |
| CHEMBL277132 | — | IC50 | = | 4900.0 | nM | 5.31 |
| CHEMBL412600 | — | IC50 | = | 9300.0 | nM | 5.03 |
| CHEMBL387437 | — | IC50 | = | 13300.0 | nM | 4.88 |
| CHEMBL415339 | — | IC50 | = | 16000.0 | nM | 4.80 |