Assay Detail
Functional
CHEMBL683703
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Compound was evaluated for its activity in vitro with use of isolated guinea pig tracheal spiral strips in the presence (control )
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cavia porcellus |
| Tissue | Trachea |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Chemically stable homocinnamyl analogues of the leukotrienes: synthesis and preliminary biological evaluation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 13 | 6.15 | 8.47 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL82239 | — | — | 1 | 8.47 |
| CHEMBL288943 | LEUKOTRIENE D4 | -1.0 | 1 | 8.41 |
| CHEMBL82177 | — | — | 1 | 8.38 |
| CHEMBL85191 | — | — | 1 | 6.24 |
| CHEMBL315406 | — | — | 1 | 5.89 |
| CHEMBL52757 | — | — | 1 | 5.87 |
| CHEMBL81059 | — | — | 1 | 5.77 |
| CHEMBL3706575 | — | — | 1 | 5.57 |
| CHEMBL312591 | — | — | 1 | 5.42 |
| CHEMBL84555 | — | — | 1 | 5.32 |
| CHEMBL3706604 | — | — | 1 | 5.04 |
| CHEMBL3706607 | — | — | 1 | 4.89 |
| CHEMBL83672 | — | — | 1 | 4.73 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL82239 | — | EC50 | = | 3.37 | nM | 8.47 |
| CHEMBL288943 | LEUKOTRIENE D4 | EC50 | = | 3.92 | nM | 8.41 |
| CHEMBL82177 | — | EC50 | = | 4.16 | nM | 8.38 |
| CHEMBL85191 | — | EC50 | = | 574.0 | nM | 6.24 |
| CHEMBL315406 | — | EC50 | = | 1280.0 | nM | 5.89 |
| CHEMBL52757 | — | EC50 | = | 1360.0 | nM | 5.87 |
| CHEMBL81059 | — | EC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL3706575 | — | EC50 | = | 2680.0 | nM | 5.57 |
| CHEMBL312591 | — | EC50 | = | 3820.0 | nM | 5.42 |
| CHEMBL84555 | — | EC50 | = | 4830.0 | nM | 5.32 |
| CHEMBL3706604 | — | EC50 | = | 9100.0 | nM | 5.04 |
| CHEMBL3706607 | — | EC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL83672 | — | EC50 | = | 18600.0 | nM | 4.73 |