Assay Detail
Functional
CHEMBL683707
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Compound was evaluated for its activity in vitro with use of isolated guinea pig tracheal spiral strips in the presence of L-cysteine (3 mM)
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cavia porcellus |
| Tissue | Trachea |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Chemically stable homocinnamyl analogues of the leukotrienes: synthesis and preliminary biological evaluation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 6.74 | 9.29 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL288943 | LEUKOTRIENE D4 | -1.0 | 1 | 9.29 |
| CHEMBL3706575 | — | — | 1 | 6.60 |
| CHEMBL3706609 | — | — | 1 | 5.73 |
| CHEMBL3706605 | — | — | 1 | 5.32 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL288943 | LEUKOTRIENE D4 | EC50 | = | 0.513 | nM | 9.29 |
| CHEMBL3706575 | — | EC50 | = | 251.0 | nM | 6.60 |
| CHEMBL3706609 | — | EC50 | = | 1870.0 | nM | 5.73 |
| CHEMBL3706605 | — | EC50 | = | 4770.0 | nM | 5.32 |