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Assay Detail

CHEMBL683768

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Inhibition of CCK-8-stimulated amylase release
38
Total Activities
38
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Cavia porcellus
Confidence 1 — Organism
Curated By Expert

Target

Cavia porcellus (CHEMBL369)
Type ORGANISM
Organism Cavia porcellus

Publication

Cholecystokinin antagonists: (R)-tryptophan-based hybrid antagonists of high affinity and selectivity for CCK-A receptors.
Kerwin JF, Wagenaar F, Kopecka H, Lin CW, Miller T, Witte D, Stashko M, Nadzan AM.
J Med Chem (1991) 34 : 3350 -3359
PubMed 1766000 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 38 6.73 7.80

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL112307 1 7.80
CHEMBL324022 1 7.57
CHEMBL112222 1 7.44
CHEMBL114325 AMIGLUMIDE 2.0 1 7.44
CHEMBL115656 1 7.37
CHEMBL112682 1 7.34
CHEMBL114913 1 7.21
CHEMBL322284 1 6.97
CHEMBL321811 1 6.96
CHEMBL115269 1 6.96
CHEMBL9485 1 6.75
CHEMBL112215 1 6.55
CHEMBL111837 1 6.44
CHEMBL444847 1 6.17
CHEMBL324652 1 5.89
CHEMBL114980 1 5.60
CHEMBL113041 1 4.00
CHEMBL320976 1 -
CHEMBL325220 1 -
CHEMBL323854 1 -
CHEMBL267339 1 -
CHEMBL115456 1 -
CHEMBL325160 1 -
CHEMBL323245 1 -
CHEMBL322031 1 -
CHEMBL419031 1 -
CHEMBL111808 1 -
CHEMBL450883 1 -
CHEMBL419585 1 -
CHEMBL422603 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL112307 IC50 = 16.0 nM 7.80
CHEMBL324022 IC50 = 27.0 nM 7.57
CHEMBL112222 IC50 = 36.0 nM 7.44
CHEMBL114325 AMIGLUMIDE IC50 = 36.0 nM 7.44
CHEMBL115656 IC50 = 43.0 nM 7.37
CHEMBL112682 IC50 = 46.0 nM 7.34
CHEMBL114913 IC50 = 62.0 nM 7.21
CHEMBL322284 IC50 = 106.0 nM 6.97
CHEMBL321811 IC50 = 110.0 nM 6.96
CHEMBL115269 IC50 = 110.0 nM 6.96
CHEMBL9485 IC50 = 180.0 nM 6.75
CHEMBL112215 IC50 = 280.0 nM 6.55
CHEMBL111837 IC50 = 360.0 nM 6.44
CHEMBL444847 IC50 = 670.0 nM 6.17
CHEMBL324652 IC50 = 1300.0 nM 5.89
CHEMBL114980 IC50 = 2500.0 nM 5.60
CHEMBL113041 IC50 = 100000.0 nM 4.00
CHEMBL115093 IC50 > 30000.0 nM -
CHEMBL114997 IC50 < 100000.0 nM -
CHEMBL112622 IC50 > 100000.0 nM -
CHEMBL112054 IC50 > 100000.0 nM -
CHEMBL323249 IC50 < 100000.0 nM -
CHEMBL112612 IC50 < 100000.0 nM -
CHEMBL114916 IC50 < 100000.0 nM -
CHEMBL325067 IC50 < 100000.0 nM -
CHEMBL422603 IC50 > 100000.0 nM -
CHEMBL419585 IC50 < 30000.0 nM -
CHEMBL450883 IC50 > 100000.0 nM -
CHEMBL111808 IC50 < 30000.0 nM -
CHEMBL419031 IC50 < 100000.0 nM -
CHEMBL322031 IC50 > 100000.0 nM -
CHEMBL323245 IC50 < 30000.0 nM -
CHEMBL325160 IC50 > 100000.0 nM -
CHEMBL115456 IC50 < 100000.0 nM -
CHEMBL267339 IC50 > 30000.0 nM -
CHEMBL323854 IC50 < 10000.0 nM -
CHEMBL325220 IC50 < 10000.0 nM -
CHEMBL320976 IC50 < 10000.0 nM -