Assay Detail
Functional
CHEMBL683778
Review assay metadata, readout intent, target linkage, and publication context from the same page.
in vitro inhibition of electrically evoked contractions of GPI (Guinea pig ileum)
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cavia porcellus |
| Tissue | Ileum |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Pseudoproline-containing analogues of morphiceptin and endomorphin-2: evidence for a cis Tyr-Pro amide bond in the bioactive conformation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.23 | 8.11 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL333357 | ENDOMORPHIN 2 | — | 1 | 8.11 |
| CHEMBL2370620 | — | — | 1 | 6.96 |
| CHEMBL35838 | [LEU5]ENKEPHALIN | — | 1 | 6.61 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL333357 | ENDOMORPHIN 2 | IC50 | = | 7.71 | nM | 8.11 |
| CHEMBL2370620 | — | IC50 | = | 109.0 | nM | 6.96 |
| CHEMBL35838 | [LEU5]ENKEPHALIN | IC50 | = | 246.0 | nM | 6.61 |