Assay Detail
Functional
CHEMBL683873
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Single-point analysis using 5(10e-9) M concentration of the antagonist (pA2= -log([B]/concentration ratio-1); [B] =concentration of the antagonist).
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cavia porcellus |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Benzimidazole derivatives. 2. Synthesis and structure-activity relationships of new azabicyclic benzimidazole-4-carboxylic acid derivatives with affinity for serotoninergic 5-HT(3) receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 2 | 9.55 | 9.90 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL46 | ONDANSETRON | 4.0 | 1 | 9.90 |
| CHEMBL289469 | GRANISETRON | 4.0 | 1 | 9.20 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL46 | ONDANSETRON | Kd | = | 0.1259 | nM | 9.90 |
| CHEMBL289469 | GRANISETRON | Kd | = | 0.631 | nM | 9.20 |