Assay Detail

CHEMBL683874

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Functional

Tested for antagonism of the contractile effect on guinea pig ileum preparations

ChEMBL ↗

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Target

Cavia porcellus (CHEMBL369) ↗

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Primary target Cavia porcellus

CHEMBL369

Anchored from Assay target.

Protein identity Cavia porcellus

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Cavia porcellus
Tissue	Ileum
Confidence	1 — Organism
Curated By	Intermediate

Target

Cavia porcellus (CHEMBL369) ↗

Type	ORGANISM
Organism	Cavia porcellus

Publication

Synthesis of RPR 100893, prototype of a new series of potent and selective non peptide NK1 antagonists : the triarylperhydroisoindolols.

Tabart M, Peyronel J
Bioorg Med Chem Lett (1994) 4 : 673 -676
· DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
Kd	1	8.05	8.05

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL38824	DAPITANT	2.0	1	8.05

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL38824	DAPITANT	Kd	=	8.913	nM	8.05