Assay Detail

CHEMBL684106

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Functional

Agonist activity in the guinea pig ileum longitudinal muscle myenteric plexus.

ChEMBL ↗

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Target

Cavia porcellus (CHEMBL369) ↗

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Primary target Cavia porcellus

CHEMBL369

Anchored from Assay target.

Protein identity Cavia porcellus

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Cavia porcellus
Tissue	Ileum
Confidence	1 — Organism
Curated By	Intermediate

Target

Cavia porcellus (CHEMBL369) ↗

Type	ORGANISM
Organism	Cavia porcellus

Publication

10-Ketonaltrexone and 10-ketooxymorphone.

Archer S, Seyed-Mozaffari A, Ward S, Kosterlitz HW, Paterson SJ, McKnight AT, Corbett AD.
J Med Chem (1985) 28 : 974 -976
PubMed 2409281 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	2	7.62	7.62

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL963	OXYMORPHONE	4.0	1	7.62
CHEMBL175304	KETOXYMORPHONE	—	1	-

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL963	OXYMORPHONE	IC50	=	24.0	nM	7.62
CHEMBL175304	KETOXYMORPHONE	IC50	>	1000.0	nM	-