Assay Detail
Functional
CHEMBL684110
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Antagonist activity was calculated as the concentration which produced a 50% reduction in the submaximal of 5-HT induced contractions guinea pig ileum
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cavia porcellus |
| Tissue | Ileum |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Arylcarbamate derivatives of 1-piperidineethanol as potent ligands for 5-HT4 receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 7.45 | 7.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL50660 | — | — | 1 | 7.96 |
| CHEMBL33884 | — | — | 1 | 7.89 |
| CHEMBL301510 | — | — | 1 | 7.52 |
| CHEMBL298920 | — | — | 1 | 7.21 |
| CHEMBL287045 | — | — | 1 | 7.11 |
| CHEMBL2115017 | — | — | 1 | 7.00 |
| CHEMBL300476 | — | — | 1 | - |
| CHEMBL48351 | — | — | 1 | - |
| CHEMBL51251 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL50660 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL33884 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL301510 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL298920 | — | IC50 | = | 62.0 | nM | 7.21 |
| CHEMBL287045 | — | IC50 | = | 77.0 | nM | 7.11 |
| CHEMBL2115017 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL300476 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL48351 | — | IC50 | ~ | 1000.0 | nM | - |
| CHEMBL51251 | — | IC50 | ~ | 300.0 | nM | - |