Assay Detail
Functional
CHEMBL684115
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In-vitro potency on the isolated guinea pig gallbladder
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cavia porcellus |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Discovery of 1,5-benzodiazepines with peripheral cholecystokinin (CCK-A) receptor agonist activity (II): Optimization of the C3 amino substituent.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 7.68 | 9.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1121 | SINCALIDE | 4.0 | 1 | 9.10 |
| CHEMBL358778 | — | — | 1 | 7.90 |
| CHEMBL147186 | — | — | 1 | 7.40 |
| CHEMBL356408 | — | — | 1 | 6.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1121 | SINCALIDE | EC50 | = | 0.7943 | nM | 9.10 |
| CHEMBL358778 | — | EC50 | = | 12.59 | nM | 7.90 |
| CHEMBL147186 | — | EC50 | = | 39.81 | nM | 7.40 |
| CHEMBL356408 | — | EC50 | = | 501.19 | nM | 6.30 |