Assay Detail
Functional
CHEMBL684128
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Functional antagonism was obtained by the ability of compound to inhibit stimulation of [35S]GTP gamma S binding produced by selective agonists U69,593 in guinea pig caudate membranes
5
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cavia porcellus |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Importance of phenolic address groups in opioid kappa receptor selective antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 9.46 | 10.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL415247 | JDTIC | 1.0 | 1 | 10.70 |
| CHEMBL573214 | NORBINALTORPHIMINE | — | 2 | 10.42 |
| CHEMBL10986 | — | — | 1 | 8.33 |
| CHEMBL10872 | — | — | 1 | 7.94 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL415247 | JDTIC | Ki | = | 0.02 | nM | 10.70 |
| CHEMBL573214 | NORBINALTORPHIMINE | Ki | = | 0.038 | nM | 10.42 |
| CHEMBL573214 | NORBINALTORPHIMINE | Ki | = | 0.13 | nM | 9.89 |
| CHEMBL10986 | — | Ki | = | 4.7 | nM | 8.33 |
| CHEMBL10872 | — | Ki | = | 11.5 | nM | 7.94 |