Assay Detail
Functional
CHEMBL684272
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Agonist-induced SH prolongation in guinea pig isolated heart was determined; 0.5-0.51 uM (Partial agonist)
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cavia porcellus |
| Tissue | Heart |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Affinity and intrinsic efficacy (IE) of 5'-carbamoyl adenosine analogues for the A1 adenosine receptor--efforts towards the discovery of a chronic ventricular rate control agent for the treatment of atrial fibrillation (AF).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 6.29 | 6.29 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL151050 | — | — | 1 | 6.29 |
| CHEMBL358227 | — | — | 1 | 6.29 |
| CHEMBL150348 | — | — | 1 | 6.29 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL151050 | — | EC50 | = | 510.0 | nM | 6.29 |
| CHEMBL358227 | — | EC50 | = | 510.0 | nM | 6.29 |
| CHEMBL150348 | — | EC50 | = | 510.0 | nM | 6.29 |