Assay Detail
Functional
CHEMBL684274
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist-induced SH prolongation in guinea pig isolated heart was determined; 3-5 uM (Partial agonist)
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cavia porcellus |
| Tissue | Heart |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Affinity and intrinsic efficacy (IE) of 5'-carbamoyl adenosine analogues for the A1 adenosine receptor--efforts towards the discovery of a chronic ventricular rate control agent for the treatment of atrial fibrillation (AF).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 5 | 5.30 | 5.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL150950 | — | — | 1 | 5.30 |
| CHEMBL149790 | — | — | 1 | 5.30 |
| CHEMBL356776 | — | — | 1 | 5.30 |
| CHEMBL358218 | — | — | 1 | 5.30 |
| CHEMBL392149 | TECADENOSON | 2.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL150950 | — | EC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL149790 | — | EC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL356776 | — | EC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL358218 | — | EC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL392149 | TECADENOSON | EC50 | < | 500.0 | nM | - |